Prognostic Factors and Metastatic Patterns in Primary Myxoid/Round-Cell Liposarcoma

Table 2

Factors leading to development of metastatic disease and risk of developing this within 5 years, showing hazards ratio estimates, 95% confidence limits and 𝑃 values.

Factor	5 years risk of metastases	HR	95% CI	𝑃 value
Overall	34%
Depth:
Superficial	28%	1
Deep	37%	1.443	0.68–3.07	0.341
Size:
Up to 5 cm	22%	0.771	0.24–2.52	0.667
> 5 cm to <10 cm	28%	0.69	0.38–1.27	0.232
>10 cm	38%	1
Site:
Lower extremity	33%	0.889	0.22–3.66	0.871
Upper extremity	40%	1
Trunk	20%	0.780	0.07–8.68	0.84
Histology:
Pure myxoid	8%	1
0–5% round cell	35%	4.166	1.36–12.78	0.0126
>5% round cell	54%	8.899	3.35–23.64	<0.0001
Margin:
Intralesional	55%	1.347	0.61–2.96	0.459
Marginal	26%	0.722	0.39–1.31	0.286
Wide	37%	1
Surgery:
Amputation	73%	3.091	1.546–6.179	0.0014
Limb salvage	29%	1
Postoperative radiotherapy	28%	0.725	0.38–1.38	0.329
No radiotherapy	36%	1