Using Epidemiology and Genomics to Understand Osteosarcoma Etiology

Table 1

Inherited disorders associated with increased rates of osteosarcoma.

Disorder	Gene	Chromosome	Autosomal inheritance pattern
Li-Fraumeni Syndrome	TP53, tumor protein p53	17p13.1	Dominant
Retinoblastoma	RB1, retinoblastoma 1	13q14.2	Dominant
Rothmund Thomson Syndrome	REQL4, RecQ protein-like 4, DNA helicase	8q24.3	Recessive
Werner Syndrome	WRN, Werner syndrome, RecQ helicase-like	8p12	Recessive
Bloom Syndrome	BLM, Bloom syndrome, RecQ helicase-like	15q26.1	Recessive
Diamond Blackfan Anemia	Ribosomal protein genes, including RPS19, RPL5, RPL11, RPL35A, RPS24, RPS17, and RPS7	multiple	Dominant