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Sarcoma
Volume 2011, Article ID 638403, 5 pages
http://dx.doi.org/10.1155/2011/638403
Research Article

Delineation of Chondroid Lipoma: An Immunohistochemical and Molecular Biological Analysis

1Department of Surgical Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands
2Department of Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands
3Department of Radiation Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands
4Department of Pathology, Academic Medical Centre, 1105 AZ, Amsterdam, The Netherlands
5Department of Pathology, University of Wuerzburg, 97074 Wuerzburg, Germany
6Department of Dermatopathology, Bodensee, D-88048 Friedrichshafen, Germany

Received 5 September 2010; Accepted 22 February 2011

Academic Editor: Peter Houghton

Copyright © 2011 Ronald S. A. de Vreeze et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation (11;16). Here, we analyze CL and its histological mimics. Methods. CL ( ) was compared to a variety of histological mimics ( ) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. Results. All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas, CCND1 was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement of CCND1 and FUS as translocation partners. Conclusions. Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.