Physeal Bystander Effects in Rhabdomyosarcoma Radiotherapy: Experiments in a New Xenograft Model

Figure 3

Serial bioluminescence imaging demonstrating successful tumor engraftment resulting from subcutaneous and intramuscular inoculation of RD-luc and RC13-luc tumor cells. (a) The growth of RD-luc tumors did not demonstrate substantial tumor growth when implanted either (b) subcutaneously or (c) intramuscularly. (d) Modest growth of RC13-luc cells were implanted (e) subcutaneously, whereas aggressive tumor growth resulted when this cell line was inoculated intramuscularly. Bar graphs show log-photon flux ±1 SD; brackets indicate 𝑃≤.05 by Student’s 𝑡-test.