The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets

Figure 1

The bone niche of chondrosarcoma is composed by various cellular entities. Chondrosarcoma tissue shows heterogeneous cell morphology (a–d) with chondrocyte-like (b–d) and mesenchymal features (f). Chondrosarcoma bone niche is associated with several cell types including osteoclasts (e), endothelial cells vascularized soft tissue (f). HES staining, original magnification (×20, a and b; ×40: c–e). Tumour cells: arrow head, asterix: blood vessels, and arrow: osteoclast.