At-Risk Populations for Osteosarcoma: The Syndromes and Beyond

Table 4

Physical findings of RecQ syndromes.

Syndrome	Cutaneous	Craniofacial	Musculoskeletal	Solid organ	Other
RTS II	Poikiloderma; Sparse Hair; Dystrophic Nails	Frontal bossing Saddle nose	Short Stature; Radial Defects; Hypoplastic Patellae	Esophageal or; Pyloric atresia; Annular pancreas	Myelodysplasi; Cataracts
RAPADILINO	No Poikiloderma	Slender Nose Cleft Palate	Short Stature; Radial Defects; Hypoplastic Patellae; Joint Dislocations	Diarrhea	Normal intelligence
Werner	Tight, atrophic skin Premature Graying	Bird-like Face	Short Stature; Flat Feet; Osteoporosis	Hypogonadism	Cataracts; Diabetes; Mellitus; Atherosclerosis
Bloom	Sun Sensitive Rash Telangiectasias	Beaked Nose Narrow Face	Short Stature	Lung disease	High Pitch Voice; Mental retardation