Targets and therapies in preclinical and clinical development in children and adolescent bone sarcomas. (A) Ewing sarcomas. (B) Osteosarcomas. The different colors described the current clinical development of the drugs. (Red) Preclinical: EW and OS; (Orange) Phase I: all paediatric studies; (Blue) Phase II: specific EW, OS, bone tumours; (Green) Phase III: specific EW and/or OS; (Black) Phase I or II in adults: all solid tumours. *17-AAG is an HSP90 inhibitor which targets client proteins involved in all tumour characteristics.
