Review Article

Osteosarcoma Models: From Cell Lines to Zebrafish

Figure 6

Cell migration, angiogenesis, and host response. Schematic representation of a transgenic zebrafish embryo in which all blood vessels are labeled in green. After injection of cells labeled in red, the transparent embryos are screened daily to investigate processes like intra/extravasation, migration (metastasis), and signs of angiogenesis. In addition, by labeling immune cells with another color (blue in this figure) or by examining the zebrafish gene expression profiles, the host response to the injected cells can be studied.
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