Alveolar Soft Part Sarcomas: Molecular Pathogenesis and Implications for Novel Targeted Therapies

Table 1

Translocations involving the TFE3 gene.

Fusion protein	Genetic translocation	Function of gene N-terminal to TFE3	Reference
TFE-ASPSCR-1	t(X;17)(p11;25)	Tether-containing UBX domain for GLUT4 (ASPSCR-1)	Ladanyi et al. [22, 24]
TFE-PRCC	t(X;1)(p11.2;q21.2)	Papillary renal cell carcinoma translocation-associated (PRCC) gene	Weterman et al. [33] and Sidhar et al. [34]
TFE-PSF	t(X;1)(p11.2;p34)	PTB-associated splicing factor (PSF)	Clark et al. [35]
TFE-NonO	inv(X)(p11.2;q12)	Non-POU-domain-containing, octamer-binding (NonO) gene	Clark et al. [35]
TFE-CLTC	t(X;17)(p11.2;q23)	Clathrin heavy-chain (CLTC) gene	Argani et al. [36]
Unknown	t(X;10)(p11.2;q23)	Unknown	Dijkhuizen et al. [37]
Unknown	t(X;3)(p11;q23)	Unknown	Argani et al. [38]
Unknown	t(X;19)(p11.2;q13.1)	Unknown	Armah et al. [39]