Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST
Figure 2
Pten dosage with EGFR overexpression affected enlarged dorsal root ganglia tumor multiplicity. (a) Left: representative of an early-onset peripheral nervous system phenotype observed in a 38-day Dhh-Cre; ; Cnp-EGFR (Pten/C-EGFR) experimental mouse. Brachial plexus: majority of the dorsal root ganglia and trigeminal nerves were enlarged. Middle: representative of a late-onset peripheral nervous system phenotype observed in a 104-day Dhh-Cre; (Pten) control mouse. Brachial plexus: several dorsal root ganglia and trigeminal nerves were enlarged. Right: representative of a late-onset peripheral nervous system phenotype observed in a 274-day Dhh-Cre; ; Cnp-EGFR (Pten-het/C-EGFR) control mouse. Brachial plexus: several dorsal root ganglia and trigeminal nerves were enlarged. Top panels: brachial plexi; middle panels: dorsal root ganglia; bottom panels: brain with trigeminal nerves; arrows indicate peripheral nervous system phenotype; scale bars, 2 mm. (b) Statistically significant differences in the number of enlarged dorsal root ganglia isolated from Pten/C-EGFR experimental cohort compared with control cohorts (Pten and Pten-het/C-EGFR). Mean ± standard deviation; P: unpaired t-test; n: number of mice evaluated in each cohort; N.S.: nonsignificant.
