Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST

Table 1

Occurrence of different peripheral nervous system phenotype detected in various experimental and control cohorts.

Genotype	𝑁	Median survival age (days)	𝑛	Enlarged DRG (mean ± SD)	Tumor grade	BP	TN	SN	LP
𝑃𝑡𝑒𝑛^𝑓/𝑓; Cnp-EGFR	13	26	12	13.7±7.8	High	100%	92%	50%	50%
𝑃𝑡𝑒𝑛^𝑓/𝑓	12	247	10	6.7±3.8	Low	100%	90%	80%	10%
𝑃𝑡𝑒𝑛^𝑓/+; Cnp-EGFR	11	415	5	5.8±2.6	Hyperplasia/Low	100%	100%	80%	20%

All mice were transgenic for Dhh-Cre. f/f: flox/flox; f/+: flox/+; 𝑁: total number of mice in each cohort; Median: median survival age; 𝑛: number of mice examined for the occurrence of various peripheral nervous system phenotype; DRG: number of enlarged dorsal root ganglia isolated (mean ± standard deviation); Grade: tumor grade was determined by histological evaluation as described in Section 2. High: high-grade PNST; Low: low-grade PNST; Hyperplasia/Low: hyperplasia to low-grade PNST. Percentage of animals in each cohort that displayed the following peripheral nervous system phenotype; BP: enlarged brachial plexi; TN: enlarged trigeminal nerves; SN: enlarged sciatic nerves; LP: enlarged sacral plexi.