Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern
Table 1
Clinical information on the osteosarcoma samples.
Sample
Sample origin
Patient age/sex
Subtype
Grade1
Primary location
Metastasis location
Chemotherapy2
Response3
Treated sample
Metastasis (months)4
Follow-up (months)5
Status
OS3
Met
17/M
Obl/Cho
4
Femur
Lung
Yes (SSG II + VI)
NA
Yes
23
45
DD
OS4
Met
15/M
Obl
4
Femur
Lung
Yes (SSG II)
Poor
Yes
14
37
DD
OS11
Met
22/M
Par
4
Femur
Multiple6
No
—
No
185
193
DD
OS12
Met
41/M
Obl/Cho
4
Femur
Lung
Yes (SSG VI + VIII)
NA
Yes
9
49
DD
OS17
Met
18/M
Obl + Cho
4
Humerus
Lung
Yes (SSG II + VI)
NA
Yes
25
49
DD
OS18
Met
26/M
Obl
3
Fibula
Lung
No
—
No
117
353
DD
OS21
Met
17/F
Obl
4
Femur
Lung
Yes (SSG VIII)
Poor
Yes
MD
33
DD
OS23
Met
11/F
Obl
4
Femur
Lung
Yes (SSG VIII)
NA
Yes
MD
229
NED
OS25
Met
19/M
Fbl
4
Fibula
Skeleton
Yes (SSG VI + VIII)
NA
Yes
MD
44
DD
OS32
Met
24/M
Fbl
4
Tibia
Lung
Yes (SSG VI)
Poor
Yes
6
208
NED
OS53
Met
18/M
Obl/Fbl
4
Humerus
Multiple7
Yes (ISG/SSG I)
Poor
Yes
26
68
DD
OS14
Prim
14/F
Obl/Fbl
4
Femur
Lung
Yes (SSG II)
Poor
Yes
MD
13
DD
OS15
Prim
49/F
Obl
4
Costa
Lung
Yes (NA)
NA
No
MD
3
DD
OS19
Prim
16/F
Obl
4
Tibia
—
Yes (SSG VIII)
NA
Yes
—
245
NED
OS20
Prim
17/F
Obl/Fbl
4
Humerus
Soft tissue
Yes (SSG VIII)
NA
No
139
151
DD
OS29
Prim
27/F
Obl
4
Pelvis
Lung
No
—
No
MD
4
DD
OS30
Prim
21/F
Obl
4
Femur
Lung
Yes (SSG VIII)
NA
No
MD
162
NED
OS41
Prim
11/M
Obl
4
Tibia
NA
No
—
No
NA
NA
NA
OS47
Prim
12/M
SC/Pleo
4
Humerus
Lung
Yes (SSG XIV + EURAMOS I)
Good
No
92
124
NED
OS48
Prim
50/M
Obl/Fbl
4
Tibia
—
Yes (SSG XIV)
NA
No
—
74
NED
OS50
Prim
11/M
Cho
4
Femur
—
Yes (SSG XIV)
Poor
No
—
108
NED
OS51
Prim
18/F
Obl/Tel
4
Femur
Lung
Yes (ISG/SSG II)
NA
No
MD
22
DD
OS55
Prim
17/F
Obl
4
Femur
—
Yes (SSG XIV)
NA
No
—
91
NED
Abbreviations: OS, osteosarcoma; Met, metastasis; Prim, primary tumour; M, male; F, female; Obl, osteoblastic; Cho, chondroblastic; Par, parosteal; Fbl, fibroblastic; SC, spindle cell; Pleo, pleomorphic; Tel, telangiectatic; NA, not available; DD, dead of disease; NED, no evidence of disease. 1Grading is based on a four-tiered system used in the Scandinavian Sarcoma Group (SSG). 2Chemotherapy has been given according to the indicated Scandinavian Sarcoma Group (SSG) protocols, Italian Sarcoma Group/Scandinavian Sarcoma Group (ISG/SSG) protocol or European, and American Osteosarcoma Study Group (EURAMOS) protocol (for more information, see http://www.ssg-org.net/index.htm). 3Histological evaluation. 4Time to first metastasis from diagnosis. 5Time to last follow-up from diagnosis. 6Multiple locations, lung, and lymph node. 7Multiple locations, lung, and skeleton.
