Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern

Table 2

Enriched Panther pathways in the metastases compared to the primary tumours. The five most significant pathways are shown with the number of genes in the pathways. + or − signs indicate that for the genes belonging to this pathway, the distribution of fold change values is shifted towards higher or lower values, respectively, than the overall distribution of all genes that were uploaded. 𝑃-values were calculated from the Wilcoxon Rank-Sum test and Bonferroni corrected for multiple testing.

Pathways	# Genes	+/−	𝑃-value
T cell activation	134	+	5.5E–14
Inflammation mediated by chemokine and cytokine signaling pathway	299	+	2.1E–11
B cell activation	92	+	7.2E–7
EGF receptor signaling pathway	175	+	1.0E–3
Integrin signaling pathway	244	+	1.8E–3