Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern

Table 4

Top-20 genes identified by SAM analysis as differentially expressed in the comparison of primary samples from patients who developed metastases and those who did not.

Gene symbol	Gene name	Fold change	𝑑-value
CXCR4	Chemokine (C-X-C motif) receptor 4	3.1	4.3
LOC339903	—	−8.6	−3.7
TMEM37	Transmembrane protein 37	3.1	3.6
MAP3K15	Mitogen-activated protein kinase kinase kinase 15	4.1	3.4
BFSP1	Beaded filament structural protein 1, filensin	5.1	3.4
DKFZp586C0721	—	3.2	3.4
hCG1820791	—	2.7	3.3
IRX2	Iroquois homeobox protein 2	9.2	3.3
NLGN4Y	Neuroligin 4, Y-linked	−6.9	−3.3
C1QTNF7	C1q and tumor necrosis factor related protein 7	−12.5	−3.2
ARHGAP28	Rho GTPase activating protein 28	−6.7	−3.2
PRKAR2B	Protein kinase, cAMP-dependent, regulatory, type II, beta	6.8	3.2
RAPGEF4	Rap guanine nucleotide exchange factor (GEF) 4	4.1	3.2
LOC441340	—	4.1	3.2
RGS4	Regulator of G-protein signalling 4	5.8	3.1
ZNF396	Zinc finger protein 396	−2.4	−3.1
PRSS27	Protease, serine 27	−1.8	−3.1
USMG5	Upregulated during skeletal muscle growth 5	−5.9	−3.0
LENG1	Leukocyte receptor cluster (LRC) member 1	2.5	3.0
ARHGEF16	Rho guanine exchange factor (GEF) 16	4.9	3.0