Efficacy of Phosphatidylinositol-3 Kinase Inhibitors in a Primary Mouse Model of Undifferentiated Pleomorphic Sarcoma
Figure 5
(a) Tumor volume of mice treated with BEZ235 alone (red) or BEZ235+doxorubicin (black). The average growth of vehicle-treated tumors (blue) from Figure 2 is shown for comparison. (b) Waterfall plot of tumor volume response for BEZ235 (black bars) and BEZ235+doxorubicin (shaded bars). Data is presented as percent maximal loss in tumor volume for animals responding to treatment and as percent maximal gain in tumor volume for nonresponders. Tumors that began treatment below 250 mm3 are marked with an asterisk (*).
