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Sarcoma
Volume 2012, Article ID 680708, 8 pages
http://dx.doi.org/10.1155/2012/680708
Research Article

Efficacy of Phosphatidylinositol-3 Kinase Inhibitors in a Primary Mouse Model of Undifferentiated Pleomorphic Sarcoma

1Department of Radiation Oncology, Duke University Medical Center, Box 91006, Durham, NC 27710, USA
2Department of Radiation Oncology, Boramae Hospital, Seoul National University Hospital, Seoul 156-707, Republic of Korea
3Department of Pharmacology and Cancer Biology, Duke University Medical Center, Box 91006, Durham, NC 27710, USA
4Department of Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul 156-707, Republic of Korea
5Division of Medical Oncology, Duke University Medical Center, Box 91006, Durham, NC 27710, USA

Received 4 January 2012; Revised 10 February 2012; Accepted 13 February 2012

Academic Editor: Luca Sangiorgi

Copyright © 2012 Suzy Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

To assess potential toxicity following drug treatment, mice were monitored for changes in body weight. Tumor-bearing mice were treated with doxorubicin alone (A), BKM120 alone (C) or BKM120 + doxorubicin (D). Healthy, wild-type 129/SvJae mice were treated with BEZ235 + doxorubicin (B) for two weeks to monitor toxicity.

  1. Supplementary Figuers