Sarcoma

Clinical Study

Quality of Life and Utility in Patients with Metastatic Soft Tissue and Bone Sarcoma: The Sarcoma Treatment and Burden of Illness in North America and Europe (SABINE) Study

Table 5

Patients’ QoL based on the QLQ-C30.


	Statistic	All	mSTS	mBS	General pop.³

Global health status
QoL	Mean score (SD)	62.2 (22.8)	62.0 (22.5)	63.3 (24.5)	76.4, (21.8)
	Median	66.7	66.7	66.7
	Min, max	16.7, 100	16.7, 100	25, 100
	95% CI	58, 66.5	57.4, 66.6	51.8, 74.8
Functional scale ¹
Physical functioning	Mean score (SD)	75.0 (19.8)	74.4 (20.3)	78.0 (17.0)	89.4, (17.2)
	SD
	Min, max	26.7, 100	26.7, 100	46.7, 100
	95% CI	71.3, 78.7	70.2, 78.5	70, 86
Role functioning	Mean score (SD)	60.6 (33.6)	62.3 (32.9)	52.5 (36.4)	86.5, (24.4)
	Min, max	0, 100	0, 100	0, 100
	95% CI	54.5, 66.8	55.7, 69	35.5, 69.5
Emotional functioning	Mean score (SD)	72.6 (23.2)	72.6 (23.3)	72.9 (23.2)	81.2, (21.1)
	Min, max	0, 100	0, 100	8.3, 100
	95% CI	68.4, 76.9	67.8, 77.3	62, 83.8
Cognitive functioning	Mean score (SD)	83.2 (21.9)	84.2 (19.6)	78.3 (31.1)	88.4, (17.4)
	Min, Max	0, 100	0, 100	16.7, 100
	95% CI	79.2, 87.2	80.2, 88.2	63.8, 92.9
Social functioning	Mean score	65.9 (29.1)	65.8 (29.5)	66.7 (28.1)	90.8, (19.5)
	Min, max	0, 100	0, 100	0, 100
	95% CI	60.6, 71.3	59.8, 71.8	53.5, 79.8
Symptoms scale²
Fatigue	Mean score (SD)	40.1 (28.4)	40.0 (28.5)	40.6 (28.2)	21, (21.7)
	Min, max	0, 100	0, 100	0, 100
	95% CI	34.9, 45.3	34.3, 45.8	27.3, 53.8
Nausea and vomiting	Mean score (SD)	13.8 (20.7)	14.6 (21.3)	10.0 (17.4)	3.3, (10.7)
	Min, max	0, 100	0, 100	0, 66.7
	95% CI	10, 17.6	10.3, 18.9	1.8, 18.2
Pain	Mean score (SD)	27.6 (27.2)	27.6 (27.3)	27.5 (27.2)	18.8, (25.5)
	Min, max	0, 100	0, 100	0, 83.3
	95% CI	22.6, 32.6	22.1, 33.1	14.8, 40.2
Dyspnoea	Mean score (SD)	22.7 (26.2)	22.6 (26.3)	23.3 (26.7)	17.4, (26)
	Min, max	0, 100	0, 100	0, 66.7
	95% CI	17.9, 27.5	17.2, 27.9	10.8, 35.8
Insomnia	Mean score (SD)	28.9 (29.9)	28.4 (29.7)	31.7 (31.5)	17.9, (26.3)
	Min, max	0, 100	0, 100	0, 100
	95% CI	23.4, 34.5	22.3, 34.5	16.9, 46.4
Appetite loss	Mean score (SD)	19.8 (27.1)	21.2 (28.7)	13.3 (16.8)	4.3, (14.7)
	Min, max	0, 100	0, 100	0, 33.3
	95% CI	14.8, 24.8	15.4, 27	5.5, 21.2
Constipation	Mean score (SD)	24.7 (30.5)	26.4 (31.3)	16.7 (25.4)	5.2, (15.7)
	Min, max	0, 100	0, 100	0, 66.7
	95% CI	19.1, 30.3	20, 32.7	4.8, 28.5
Diarrhea	Mean score (SD)	11.8 (22.9)	11.1 (20.3)	15.0 (33.3)	5.2, (15.4)
	Min, max	0, 100	0, 66.7	0, 100
	95% CI	7.6, 16	7, 15.2	−0.6, 30.6
Financial difficulties	Mean score (SD)	26.1 (32.4)	25.3 (32.5)	30.0 (32.3)	7, (19.7)
	Min, max	0, 100	0, 100	0, 100
	95% CI	20.1, 32.1	18.6, 31.9	14.9, 45.1

Note: The following scales had missing values: Global QoL, physical functioning, Insomnia, and financial difficulties ¹a higher score indicates better quality of life ²a higher score indicates more symptoms; ³General population values, age and sex adjusted for SABINE population [17].