Table of Contents Author Guidelines Submit a Manuscript
Sarcoma
Volume 2012 (2012), Article ID 749067, 4 pages
http://dx.doi.org/10.1155/2012/749067
Research Article

Topotecan and Cyclophosphamide in Adults with Relapsed Sarcoma

1Department of Internal Medicine, University of Toronto, Toronto, Canada
2Department of Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Canada
3University Musculoskeletal Oncology Unit, Division of Orthopaedic Surgery, Mount Sinai Hospital, University of Toronto, Canada
4Division of General Surgery, Mount Sinai Hospital, University of Toronto, Canada
5Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Canada

Received 1 May 2012; Accepted 1 June 2012

Academic Editor: Luca Sangiorgi

Copyright © 2012 P. Blanchette et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. Sultan, I. Qaddoumi, S. Yaser, C. Rodriguez-Galindo, and A. Ferrari, “Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients,” Journal of Clinical Oncology, vol. 27, no. 20, pp. 3391–3397, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Al-Hussaini, D. Hogg, M. E. Blackstein et al., “Clinical features, treatment, and outcome in 102 adult and pediatric patients with localized high-grade synovial sarcoma,” Sarcoma, vol. 2011, Article ID 231789, 7 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. A. A. Gupta, A. Pappo, N. Saunders et al., “Clinical outcome of children and adults with localized ewing sarcoma: impact of chemotherapy dose and timing of local therapy,” Cancer, vol. 116, no. 13, pp. 3189–3194, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Scurr and I. Judson, “How to treat the Ewing's family of sarcomas in adult patients,” Oncologist, vol. 11, no. 1, pp. 65–72, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. R. B. Womer, D. C. West, M. D. Krailo, P. S. Dickman, and B. Pawel, “Randomized comparison of every-two-week v. every-three-week chemotherapy in Ewing sarcoma family tumors (ESFT),” Journal of Clinical Oncology, vol. 26, supplement, abstract 10504, no. 15S, 2008. View at Google Scholar
  6. Y. Pommier, “Eukaryotic DNA topoisomerase I: genome gatekeeper and its intruders, camptothecins,” Seminars in Oncology, vol. 23, no. 1, supplement, pp. 3–10, 1996. View at Google Scholar · View at Scopus
  7. R. L. Saylors, K. C. Stine, J. Sullivan et al., “Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a pediatric oncology group phase II study,” Journal of Clinical Oncology, vol. 19, no. 15, pp. 3463–3469, 2001. View at Google Scholar · View at Scopus
  8. D. O. Walterhouse, E. R. Lyden, P. P. Breitfeld, S. J. Qualman, M. D. Wharam, and W. H. Meyer, “Efficacy of topotecan and cyclophosphamide given in a phase II window trial in children with newly diagnosed metastatic rhabdomyosarcoma: a children's oncology group study,” Journal of Clinical Oncology, vol. 22, no. 8, pp. 1398–1403, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Hunold, N. Weddeling, M. Paulussen, A. Ranft, C. Liebscher, and H. Jürgens, “Topotecan and cyclophosphamide in patients with refractory or relapsed Ewing tumors,” Pediatric Blood and Cancer, vol. 47, no. 6, pp. 795–800, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. M. L. Bernstein, M. Devidas, D. Lafreniere et al., “Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: pediatric oncology group/children's cancer group phase II study 9457—a report from the children's oncology group,” Journal of Clinical Oncology, vol. 24, no. 1, pp. 152–159, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. http://www.clinicaltrials.gov/ct2/show/NCT00618813?term=AEWS07P1&rank=1, 2011.
  12. E. A. Eisenhauer, P. Therasse, J. Bogaerts et al., “New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1),” European Journal of Cancer, vol. 45, no. 2, pp. 228–247, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. S. J. Cotterill, S. Ahrens, M. Paulussen et al., “Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group,” Journal of Clinical Oncology, vol. 18, no. 17, pp. 3108–3114, 2000. View at Google Scholar · View at Scopus
  14. J. R. Park, J. R. Scott, C. F. Stewart et al., “Pilot induction regimen incorporating pharmacokinetically guided topotecan for treatment of newly diagnosed high-risk neuroblastoma: a Children's Oncology Group study,” Journal of Clinical Oncology, vol. 29, no. 33, pp. 4351–4357, 2011. View at Google Scholar
  15. T. Macarulla, E. Rodriguez-Braun, J. Tabernero et al., “Phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of the selective aurora A kinase (AAK) inhibitor MLN8054 in patients (pts) with advanced solid tumors,” Journal of Clinical Oncology, vol. 27, no. 15S, article 2578, 2009. View at Google Scholar
  16. J. S. McCune, A. Batchelder, H. J. Deeg et al., “Cyclophosphamide following targeted oral busulfan as conditioning for hematopoietic cell transplantation: pharmacokinetics, liver toxicity, and mortality,” Biology of Blood and Marrow Transplantation, vol. 13, no. 7, pp. 853–862, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. J. S. McCune, A. Batchelder, K. A. Guthrie et al., “Personalized dosing of cyclophosphamide in the total body irradiation-cyclophosphamide conditioning regimen: a phase II trial in patients with hematologic malignancy,” Clinical Pharmacology and Therapeutics, vol. 85, no. 6, pp. 615–622, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. J. S. McCune, D. H. Salinger, P. Vicini, C. Oglesby, D. K. Blough, and J. R. Park, “Population pharmacokinetics of cyclophosphamide and metabolites in children with neuroblastoma: a report from the children's oncology group,” Journal of Clinical Pharmacology, vol. 49, no. 1, pp. 88–102, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. A. A. Gupta, J. R. Anderson, A. S. Pappo et al., “Patterns of chemotherapy-induced toxicities in younger children and adolescents with rhabdomyosarcoma: a Report From the Children's Oncology Group Soft Tissue Sarcoma Committee,” Cancer, vol. 118, no. 4, pp. 1130–1137, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. D. A. Casey, L. H. Wexler, M. S. Merchant et al., “Irinotecan and temozolomide for Ewing sarcoma: the memorial sloan-kettering experience,” Pediatric Blood and Cancer, vol. 53, no. 6, pp. 1029–1034, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. L. M. Wagner, N. McAllister, R. E. Goldsby et al., “Temozolomide and intravenous irinotecan for treatment of advanced Ewing sarcoma,” Pediatric Blood and Cancer, vol. 48, no. 2, pp. 132–139, 2007. View at Publisher · View at Google Scholar · View at Scopus