Research Article

Comparative Gene Expression Profiling of Benign and Malignant Lesions Reveals Candidate Therapeutic Compounds for Leiomyosarcoma

Figure 2

Connectivity Map to identify drugs to target leiomyosarcoma subtypes. Unsupervised hierarchical clustering of the drugs (along the -axis) and three LMS subtypes (along the -axis). The heatmap displays the enrichment score of each drug with each LMS subtype. Green indicates negative enrichment and red indicates positive enrichment. We used these data to test whether the direction and/or magnitude of cmap enrichment scores could predict drug response in LMS cell lines. Full results from the Connectivity Map analysis are provided in Supplemental Table  S4.
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