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Volume 2013, Article ID 203531, 7 pages
Review Article

Osteosarcoma: Evolution of Treatment Paradigms

1Children’s Cancer Hospital, University of Texas M.D Anderson Cancer Center, Houston, TX 77030, USA
2Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India
3Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands

Received 31 January 2013; Accepted 20 April 2013

Academic Editor: Peter Choong

Copyright © 2013 Norman Jaffe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper reviews the contribution of chemotherapy in the conquest of osteosarcoma. It discusses how the treatment of osteosarcoma has evolved over the last five decades, resulting in a more than fivefold increase in survival. Though the initial improvements in survival were dramatic, essentially there has been no change in the outlook for this disease over the past 30 years. The paper also highlights the necessity of a multidisciplinary approach to combat this disease and stresses the need to explore newer treatment agents in order to build on the lessons learnt from the past while striving to achieve greater levels of success.