Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells
LBH589 reduces osteosarcoma tumour growth and drives osteoblast differentiation in vivo. (a) U2OS xenograft flank tumours treated with vehicle control or 10 mg/kg LBH589 i.p. daily for 6 days. Bar = 5 mm. (b) Tumour volume. Mean ± SEM. (c) Percentage body weight. Mean ± SEM. (d) Quantitative real-time PCR of U2OS xenograft tumours following 6 consecutive days of treatment with vehicle control for expression of osteoblast differentiation markers. *.