Research Article
Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma
Table 2
Results of DFS analysis by Cox Proportional Hazards model in no metastasis at diagnosis group
for IHH.
| Prognostic factor | Univariate | Multivariate* | HR | 95% CI | value | HR | 95% CI | value |
| IHH | | | | | | | | | High versus low | 2.66 | 0.84 | 8.40 | 0.0948 | 6.43 | 0.71 | 57.97 | 0.0970 | Size | | | | | | | | | >9 cm versus ≤9 cm | 3.52 | 1.06 | 11.67 | 0.0394 | 22.81 | 2.22 | 234.02 | 0.0085 | Necrosis | | | | | | | | | >90% versus ≤90% | 0.71 | 0.21 | 2.35 | 0.5716 | 0.53 | 0.13 | 2.14 | 0.3733 | Gender | | | | | | | | | Male versus female | 1.39 | 0.44 | 4.36 | 0.5795 | 0.22 | 0.02 | 2.25 | 0.1998 | Age (years) | 1.02 | 0.99 | 1.05 | 0.1676 | 1.03 | 0.99 | 1.07 | 0.0965 |
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Firth correction to handle small sample sizes.
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