Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma

Table 3

Results of DFS analysis by Cox Proportional Hazards model in no metastasis at diagnosis group (𝑛=32) for IHH in combination with size.

Prognostic factor	Univariate				Multivariate*
	HR	95% CI		𝑃 value	HR	95% CI		𝑃 value
IHH/size
IHH+/≤9 cm versus IHH−/≤9 cm	12.78	1.36	1694.88	0.1128*	6.31	0.47	934.10	0.2831
IHH+/>9 cm versus IHH−/≤9 cm	17.10	1.91	2253.96	0.0754*	52.30	3.27	10906.34	0.0378
IHH−/>9 cm versus IHH−/≤9 cm	20.48	2.14	2727.27	0.0611*	17.62	1.48	2614.55	0.0907
Necrosis
>90% versus ≤90%	0.71	0.21	2.35	0.5716	0.62	0.16	2.39	0.5027
Gender
Male versus female	1.39	0.44	4.36	0.5795	0.33	0.03	2.10	0.2700
Age (years)	1.02	0.99	1.05	0.1676	1.03	0.99	1.07	0.2034

∗Firth correction to handle small sample sizes.
IHH+: high IHH levels.
IHH−: low IHH levels.