Sarcoma / 2014 / Article / Tab 3

Research Article

Aberrant Hedgehog Signaling and Clinical Outcome in Osteosarcoma

Table 3

Results of DFS analysis by Cox Proportional Hazards model in no metastasis at diagnosis group for IHH in combination with size.

Prognostic factorUnivariateMultivariate*
HR95% CI valueHR95% CI value

IHH/size
 IHH+/≤9 cm versus IHH−/≤9 cm12.781.361694.880.1128*6.310.47934.100.2831
 IHH+/>9 cm versus IHH−/≤9 cm17.101.912253.960.0754*52.303.2710906.340.0378
 IHH−/>9 cm versus IHH−/≤9 cm20.482.142727.270.0611*17.621.482614.550.0907
Necrosis
 >90% versus ≤90%0.710.212.350.57160.620.162.390.5027
Gender
 Male versus female1.390.444.360.57950.330.032.100.2700
 Age (years)1.020.991.050.16761.030.991.070.2034

Firth correction to handle small sample sizes.
IHH+: high IHH levels.
IHH−: low IHH levels.