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Sarcoma
Volume 2014 (2014), Article ID 402509, 10 pages
http://dx.doi.org/10.1155/2014/402509
Research Article

Osteosarcoma in Pediatric Patients and Young Adults: A Single Institution Retrospective Review of Presentation, Therapy, and Outcome

1Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
2Department of Biostatistics, School of Public Health, Yale University, New Haven, CT 06510, USA
3Sarcoma Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
4Adolescent and Young Adult Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
5Anatomic Pathology Department, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA

Received 17 January 2014; Revised 28 March 2014; Accepted 10 April 2014; Published 30 April 2014

Academic Editor: R. Lor Randall

Copyright © 2014 Candace L. Haddox et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Mirabello, R. J. Troisi, and S. A. Savage, “Osteosarcoma incidence and survival rates from 1973 to 2004: data from the surveillance, epidemiology, and end results program,” Cancer, vol. 115, no. 7, pp. 1531–1543, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. M. A. Friedman and S. K. Carter, “The therapy of osteogenic sarcoma: current status and thoughts for the future,” Journal of Surgical Oncology, vol. 4, no. 5, pp. 482–510, 1972. View at Google Scholar · View at Scopus
  3. G. Rosen, R. C. Marcove, and A. G. Huvos, “Primary osteogenic sarcoma: eight-year experience with adjuvant chemotherapy,” Journal of Cancer Research and Clinical Oncology, vol. 106, supplement, pp. 55–67, 1983. View at Google Scholar · View at Scopus
  4. N. M. Bernthal, N. Federman, F. R. Eilber et al., “Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma,” Cancer, vol. 118, no. 23, pp. 5888–5893, 2012. View at Google Scholar
  5. P. A. Meyers, R. Gorlick, G. Heller et al., “Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol,” Journal of Clinical Oncology, vol. 16, no. 7, pp. 2452–2458, 1998. View at Google Scholar · View at Scopus
  6. M. P. Link, A. M. Goorin, and A. W. Miser, “The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity,” New England Journal of Medicine, vol. 314, no. 25, pp. 1600–1606, 1986. View at Google Scholar · View at Scopus
  7. F. Eilber, A. Giuliano, and J. Eckhardt, “Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial,” Journal of Clinical Oncology, vol. 5, no. 1, pp. 21–26, 1987. View at Google Scholar · View at Scopus
  8. J. Schrager, R. E. Patzer, P. J. Mink, K. C. Ward, and M. Goodman, “Survival outcomes of pediatric osteosarcoma and Ewing's sarcoma: a comparison of surgery type within the SEER database, 1988–2007,” Journal of registry management, vol. 38, no. 3, pp. 153–161, 2011. View at Google Scholar · View at Scopus
  9. G. A. Marulanda, E. R. Henderson, D. A. Johnson, G. D. Letson, and D. Cheong, “Orthopedic surgery options for the treatment of primary osteosarcoma,” Cancer Control, vol. 15, no. 1, pp. 13–20, 2008. View at Google Scholar · View at Scopus
  10. M. A. Ayerza, G. L. Farfalli, L. Aponte-Tinao, and D. Luis Muscolo, “Does increased rate of limb-sparing surgery affect survival in osteosarcoma?” Clinical Orthopaedics and Related Research, vol. 468, no. 11, pp. 2854–2859, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Marina, S. Bielack, J. Whelan et al., “International collaboration is feasible in trials for rare conditions: the EURAMOS experience,” Cancer Treatment and Research, vol. 152, pp. 339–353, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. S. S. Bielack, B. Kempf-Bielack, G. Delling et al., “Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols,” Journal of Clinical Oncology, vol. 20, no. 3, pp. 776–790, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Fuchs, S. S. Bielack, D. Epler et al., “Long-term results of the co-operative German-Austrian-Swiss osteosarcoma study group's protocol COSS-86 of intensive multidrug chemotherapy and surgery for osteosarcoma of the limbs,” Annals of Oncology, vol. 9, no. 8, pp. 893–899, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. K. A. Janeway, D. A. Barkauskas, M. D. Krailo et al., “Outcome for adolescent and young adult patients with osteosarcoma: a report from the Children's Oncology Group,” Cancer, vol. 118, no. 18, pp. 4597–4605, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. J. A. Lee, M. S. Kim, D. H. Kim et al., “Risk stratification based on the clinical factors at diagnosis is closely related to the survival of localized osteosarcoma,” Pediatric Blood and Cancer, vol. 52, no. 3, pp. 340–345, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. H. J. Mankin, F. J. Hornicek, A. E. Rosenberg, D. C. Harmon, and M. C. Gebhardt, “Survival data for 648 patients with osteosarcoma treated at one institution,” Clinical Orthopaedics and Related Research, no. 429, pp. 286–291, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Bleyer, M. Montello, T. Budd, and S. Saxman, “National survival trends of young adults with sarcoma: lack of progress is associated with lack of clinical trial participation,” Cancer, vol. 103, no. 9, pp. 1891–1897, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Bleyer, “Young adult oncology: the patients and their survival challenges,” CA Cancer Journal for Clinicians, vol. 57, no. 4, pp. 242–255, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. J. V. Tricoli, N. L. Seibel, D. G. Blair, K. Albritton, and B. Hayes-Lattin, “Unique characteristics of adolescent and young adult acute lymphoblastic leukemia, breast cancer, and colon cancer,” Journal of the National Cancer Institute, vol. 103, no. 8, pp. 628–635, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. K. H. Albritton and T. Eden, “Access to care,” Pediatric Blood and Cancer, vol. 50, no. 5, supplement, pp. 1094–1098, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Dang-Tan, H. Trottier, L. S. Mery et al., “Delays in diagnosis and treatment among children and adolescents with cancer in Canada,” Pediatric Blood and Cancer, vol. 51, no. 4, pp. 468–474, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Downs-Canner and P. H. Shaw, “A comparison of clinical trial enrollment between adolescent and young adult (aya) oncology patients treated at affiliated adult and pediatric oncology centers,” Journal of Pediatric Hematology/Oncology, vol. 31, no. 12, pp. 927–929, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Ferrari, M. Montello, T. Budd, and A. Bleyer, “The challenges of clinical trials for adolescents and young adults with cancer,” Pediatric Blood and Cancer, vol. 50, no. 5, supplement, pp. 1101–1104, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. M. M. Hudson and C. Patte, “Education and health promotion in adolescent and young adult cancer survivors,” Pediatric Blood and Cancer, vol. 50, no. 5, supplement, pp. 1105–1108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Andreou, S. S. Bielack, D. Carrle et al., “The influence of tumor- and treatment-related factors on the development of local recurrence in osteosarcoma after adequate surgery. An analysis of 1355 patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols,” Annals of Oncology, vol. 22, no. 5, pp. 1228–1235, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. K. A. Streby, F. B. Ruymann, S. Whiteside, and N. D. Yeager, “Rhabdomyosarcoma in adolescent and young adults: a 25-year review at Nationwide Children’s Hospital,” Journal of Adolescent and Young Adult Oncology, vol. 1, no. 4, pp. 164–167, 2012. View at Google Scholar
  27. A. G. Huvos, “Pathologic assessment of preoperative (neoadjuvant) chemotherapy,” in Bone Tumors: Diagnosis, Treatment and Prognosis, vol. in, pp. 122–128, W. B. Saunders, 2nd edition, 1991. View at Google Scholar
  28. N. C. Daw, H. H. Mahmoud, W. H. Meyer et al., “Bone sarcomas of the head and neck in children: the St Jude Children's Research Hospital experience,” Cancer, vol. 88, no. 9, pp. 2172–2180, 2000. View at Google Scholar
  29. S. Jasnau, U. Meyer, J. Potratz et al., “Craniofacial osteosarcoma. Experience of the cooperative German-Austrian-Swiss osteosarcoma study group,” Oral Oncology, vol. 44, no. 3, pp. 286–294, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Thariat, M. Julieron, A. Brouchet et al., “Osteosarcomas of the mandible: are they different from other tumor sites?” Critical Reviews in Oncology/Hematology, vol. 82, no. 3, pp. 280–295, 2012. View at Publisher · View at Google Scholar
  31. J. Thariat, T. Schouman, A. Brouchet et al., “Osteosarcomas of the mandible: multidisciplinary management of a rare tumor of the young adult a cooperative study of the GSF-GETO, Rare Cancer Network, GETTEC/REFCOR and SFCE,” Annals of Oncology, vol. 24, no. 3, pp. 824–831, 2013. View at Publisher · View at Google Scholar
  32. M. Collins, M. Wilhelm, R. Conyers et al., “Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis,” Journal of Clinical Oncology, vol. 31, no. 18, pp. 2303–2312, 2013. View at Publisher · View at Google Scholar
  33. M. S. Isakoff, D. A. Barkauskas, D. Ebb, C. Morris, and G. D. Letson, “Poor survival for osteosarcoma of the pelvis: a report from the Children's Oncology Group,” Clinical Orthopaedics and Related Research, vol. 470, no. 7, pp. 2007–2013, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. S. E. Leary, A. W. Wozniak, C. A. Billups et al., “Survival of pediatric patients after relapsed osteosarcoma: the St. Jude Children's Research Hospital experience,” Cancer, vol. 119, no. 14, pp. 2645–2653, 2013. View at Publisher · View at Google Scholar
  35. G. Saeter, J. Hoie, A. E. Stenwig et al., “Systemic relapse of patients with osteogenic sarcoma. Prognostic factors for long term survival,” Cancer, vol. 75, no. 5, pp. 1084–1093, 1995. View at Google Scholar
  36. S. Ferrari, A. Briccoli, M. Mercuri et al., “Postrelapse survival in osteosarcoma of the extremities: prognostic factors for long-term survival,” Journal of Clinical Oncology, vol. 21, no. 4, pp. 710–715, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. B. Kempf-Bielack, S. S. Bielack, H. Jürgens et al., “Osteosarcoma relapse after combined modality therapy: an analysis of unselected patients in the Cooperative Osteosarcoma Study Group (COSS),” Journal of Clinical Oncology, vol. 23, no. 3, pp. 559–568, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. D. R. Freyer, J. Felgenhauer, and J. Perentesis, “Children's Oncology Group's 2013 blueprint for research: adolescent and young adult oncology,” Pediatric Blood & Cancer, vol. 60, no. 6, pp. 1055–1058, 2013. View at Google Scholar