Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre: Reassessment in the Era of Ancillary Molecular Diagnosis

Table 2

Summary of cases showing minor discrepancy.

Referral diagnosis	Final diagnosis	𝑛
Malignant	Malignant
DFSP	DFSP with fibrosarcoma	5
DFSP with fibrosarcoma	Fibrosarcoma	1
DFSP with fibrosarcoma	Spindle cell sarcoma	1
Malignant SFT	Fibrosarcoma	1
Fibrosarcoma	MPNST	1
Myxoinflammatory fibrosarcoma	Myxofibrosarcoma	1
Myxoid liposarcoma	Myxofibrosarcoma	1
Spindle cell sarcoma	Myxofibrosarcoma	1
RMS NOS	Embryonal RMS	1
RMS NOS	Pleomorphic RMS	1
RMS NOS	Myoid sarcoma	1
Myoid sarcoma	Pleomorphic RMS	1
Leiomyosarcoma	Myoid sarcoma	4
Leiomyosarcoma	Spindle cell sarcoma	1
Leiomyosarcoma	Undifferentiated neoplasm	1
Leiomyosarcoma	Myofibrosarcoma	1
MPNST	Clear cell sarcoma	1
Undifferentiated neoplasm	Clear cell sarcoma	1
PEComa, ?atypical features	PEComa, malignant	2
DDL	Spindle cell sarcoma	1
Sarcoma	Malignant neoplasm	2
Extraskeletal myxoid chondrosarcoma	Malignant neoplasm	1
Benign	Benign
Spindle cell lesion	Myxoma	1
Myxoid lesion	Myxoma	1
Benign neoplasm	Ossifying fibromyxoid tumour	1
Spindle cell lesion	Neurofibroma	1
Giant cell tumour of tendon sheath	Ossifying fibroma	1
SFT	Schwannoma	1
Fibrosis	Benign smooth muscle tumour	1
Grade	Grade
GIST 2	GIST 3	1
GIST 3	GIST 2	1
Spindle cell sarcoma 3	Myxofibrosarcoma 2	1

DFSP: dermatofibrosarcoma protuberans; DDL: dedifferentiated liposarcoma; GIST: gastrointestinal stromal tumour; MPNST: malignant peripheral nerve sheath tumour; NOS: not otherwise specified; RMS: rhabdomyosarcoma; SFT: solitary fibrous tumour.