Research Article
Comorbidity in Adult Bone Sarcoma Patients: A Population-Based Cohort Study
Table 5
Multivariate analyses for the effect of comorbidity on overall and disease-specific mortality according to histological subtype.
| Histological subtype | No. of patients | Overall mortality | Disease-specific mortality | 5-year (%) | HR (95% CI) | 5-year (%) | HR (95% CI) |
| Ewing/osteosarcoma | | | | | | No | 149 | 54 | 1 | 53 | 1 | Mild | 10 | 70 | 1.02 (0.43–2.42) | 60 | 0.80 (0.31–2.09) | Moderate | 9 | 67 | 1.12 (0.47–2.66) | 56 | 0.88 (0.33–2.36) | Severe | 8 | 38 | 0.79 (0.27–2.32) | 37 | 0.67 (0.20–2.26) | Others | | | | | | No | 219 | 30 | 1 | 22 | 1 | Mild | 27 | 45 | 1.42 (0.81–2.48) | 41 | 1.54 (0.78–3.05) | Moderate | 18 | 44 | 2.36 (1.18–4.70) | 28 | 1.05 (0.37–2.97) | Severe | 13 | 77 | 2.44 (1.30–4.58) | 46 | 2.07 (0.94–4.56) |
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Note: abbreviations: HR: hazard ratio, CI: confidence interval. Adjusted for age, stage at diagnosis, tumor size, soft tissue involvement, malignancy grade, surgical margin, and chemotherapy.
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