Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma
Table 1
Characteristics of 4,173 patients with osteosarcoma according to tissue of origin.
Characteristic
Skeletal osteosarcoma ( = 3,917)
ESOS ()
value
Mean age (range)
31.4 years*
60.7 years**
<0.0001
(0–99 years)
(9–96 years)
Sex
Male
2,175 (55.5%)
117 (45.7%)
0.002
Female
1,742 (44.5%)
139 (54.3%)
Year of diagnosis
1973–1979
395 (10.1%)
9 (3.5%)
<0.0001
1980–1989
609 (15.5%)
21 (8.2%)
1990–1999
857 (21.9%)
64 (25%)
2000–2009
2,056 (52.5%)
162 (63.3%)
Race
Caucasian
3,031 (77.8%)
212 (82.8%)
0.232
African American
536 (13.8%)
30 (11.7%)
Asian
297 (7.6%)
12 (4.7%)
Native American
32 (0.8%)
2 (0.8%)
Primary site
Lower extremity
2,392 (62.6%)
80 (32.7%)
<0.0001
Upper extremity
467 (12.2%)
18 (7.3%)
Head
398 (10.4%)
18 (7.3%)
Spine
114 (3%)
1 (0.4%)
Ribs/sternum
105 (2.8%)
0
Pelvis
343 (9%)
31 (12.7%)
Thorax
0
70 (28.6%)
Abdomen/retroperitoneum
0
27 (11%)
Primary tumor location
Axial
961 (25.1%)
154 (61.1%)
<0.0001
Appendicular
2,870 (74.9%)
98 (38.9%)
Regional lymph node
Present
61 (2.4%)
13 (7.7%)
<0.0001
Absent
2,519 (97.6%)
155 (92.3%)
Stage
Distant metastasis
794 (22.3%)
43 (18.6%)
0.188
No distant metastasis
2,763 (77.7%)
188 (81.4%)
Tumor size
<10 cm
1,252 (63.1%)
113 (58.9%)
0.241
≥10 cm
731 (36.9%)
79 (41.1%)
Radiation use
No
3,374 (87.7%)
186 (74.7%)
<0.0001
Yes
473 (12.3%)
63 (25.3%)
Histologic type
Osteosarcoma NOS
3,322 (84.8%)
239 (93.4%)
0.016
Fibroblastic OS
263 (6.7%)
10 (3.9%)
Telangiectatic OS
128 (3.3%)
3 (1.1%)
OS in Paget’s
79 (2%)
0
Small cell OS
30 (0.8%)
2 (0.8%)
Central OS
42 (1.1%)
1 (0.4%)
Periosteal OS
40 (1%)
0
High grade surface OS
13 (0.3%)
1 (0.4%)
OS: osteosarcoma; ESOS: extraskeletal osteosarcoma; NOS: not otherwise specified; totals for each variable may vary due to missing data but percentages reflect the represented data.
*Median age is 20 years. **Median age is 64 years.
