Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

Table 1

Alterations of chromosome in RMS by CGH in recent 5 years.

Materials	Gain	Amplification	Loss	Deletion	Reference
25 RMS samples	2p, 12q, 6p, 9q, 10q, 1p, 2q, 6q, 8q, 15q, 18q		3p, 11p, 6p		Li et al., 2009 [16]
13 RMS cell lines	1p21.3–13.2, 1q12, 6q26–27, 7q21.3–31.1, 1q41, 2p24.3, 8q24.12, 20q13.2, 20q13.32	2p24.3 (MYCN), 8p11.23–11.21 (FGFR1), 12q13.3 (CDK4), 19q12, 20q	3p14.2–12.2, 4q27–32.3, 6p25.1–24.3, 9p24.3–24.1, 13q14.3		Missiaglia et al., 2009 [17]
57 ARMS samples		12q15, 2p24, 12q13–q14			Barr et al., 2009 [18]
128 primary RMS samples	7, 8, 11, 20	2p24.1 (MYCN), 8p11.2–p11.1 (FGFR1), 12q13.3–14.1 (CDK4), MDM2 (12q14.3–q15)			Williamson et al., 2010 [12]
26 frozen primary ERMS samples	8, 2, 11, 12, 13, 19, 20	2p21, 2q35, 2q14.2, 2q36.1, 5q35.2–q35.3, 11p11.2, 11q24.2, 12q13.3	6, 9, 10, 14, 15, 16, 18	1p36.23, 1q32.1, 3p14.2, 4q35.1–35.2, 9p21.3, 17q11.2, 22q13.31	Paulson et al., 2011 [13]
39 RMS samples	12q13.3, 12q13.3–q14.1, 12q14.1, 17q25.1	2q13.12, 12q13.3, 12q13.3–q14.1	9p12–p11.2, 10q11.21–q11.22, 14q32.33, 16p11.2, 22q11.1	1p21.1, 2q14.1, 5q13.2, 9p12, 9q12	Liu et al., 2014 [11, 15]
RMS cells derived from refractory RMS		NACA, HSD17B6, SDR9C7, RDH16, GPR182, ZBTB39, TAC3, MYO1A, NAB2, STAT6, LRP1			Park et al., 2014 [14]
20 RMS samples of Chinese patients	12q24.31, 17q25.1, 1q21.1, 7q11.23, 12q13.3–q14.1	9p13.3, 12q13.3–q14.1, 12q15, 16p13.11	5q13.2, 15q11.2, 14q32.33 (IGHG, IGHM)	1p36.33, 1p13.1, 2q11.1, 5q13.2, 8p23.1, 9p24.3, 16p11.2	Liu et al., 2014 [11, 15]