Sarcoma / 2015 / Article / Tab 1

Review Article

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

Table 1

Alterations of chromosome in RMS by CGH in recent 5 years.

MaterialsGainAmplificationLossDeletionReference

25 RMS samples2p, 12q, 6p, 9q, 10q, 1p, 2q, 6q, 8q, 15q, 18q3p, 11p, 6p Li et al., 2009 [16]

13 RMS cell lines 1p21.3–13.2, 1q12, 6q26–27, 7q21.3–31.1, 1q41, 2p24.3, 8q24.12, 20q13.2, 20q13.322p24.3 (MYCN), 8p11.23–11.21 (FGFR1), 12q13.3 (CDK4), 19q12, 20q 3p14.2–12.2, 4q27–32.3, 6p25.1–24.3, 9p24.3–24.1, 13q14.3Missiaglia et al., 2009 [17]

57 ARMS samples12q15, 2p24, 12q13–q14Barr et al., 2009 [18]

128 primary RMS samples7, 8, 11, 202p24.1 (MYCN), 8p11.2–p11.1 (FGFR1), 12q13.3–14.1 (CDK4), MDM2 (12q14.3–q15)Williamson et al., 2010 [12]

26 frozen primary ERMS samples8, 2, 11, 12, 13, 19, 202p21, 2q35, 2q14.2, 2q36.1, 5q35.2–q35.3, 11p11.2, 11q24.2, 12q13.36, 9, 10, 14, 15, 16, 181p36.23, 1q32.1, 3p14.2, 4q35.1–35.2, 9p21.3, 17q11.2, 22q13.31Paulson et al., 2011 [13]

39 RMS samples12q13.3, 12q13.3–q14.1, 12q14.1, 17q25.12q13.12, 12q13.3, 12q13.3–q14.19p12–p11.2, 10q11.21–q11.22, 14q32.33, 16p11.2, 22q11.11p21.1, 2q14.1, 5q13.2, 9p12, 9q12 Liu et al., 2014 [11, 15]

RMS cells derived from refractory RMSNACA, HSD17B6, SDR9C7, RDH16, GPR182, ZBTB39, TAC3, MYO1A, NAB2, STAT6, LRP1Park et al., 2014 [14]

20 RMS samples of Chinese patients 12q24.31, 17q25.1, 1q21.1, 7q11.23, 12q13.3–q14.19p13.3, 12q13.3–q14.1, 12q15, 16p13.115q13.2, 15q11.2, 14q32.33 (IGHG, IGHM)1p36.33, 1p13.1, 2q11.1, 5q13.2, 8p23.1, 9p24.3, 16p11.2Liu et al., 2014 [11, 15]