Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

Table 2

The histological types of rhabdomyosarcoma.

Histological type	Predilection population	Predilection site	Risk category	Genetic change
ERMS	Infants or children under 10 years old	Head and neck region	Intermediate	LOH at chromosome 11p15.5
ARMS	Adolescents and young adults	Deep tissue of extremity	High	t(2;13)(q35;q14); t(1;13)(p36;q14)
PRMS	Adult males	Throughout the body	High	JUN (1p31), MYC (8q24), CCND1 (11q13), INT2 (11q13.3), MDM2 (12q14.3–q15)
SRMS	In the first decade of life with a second mode centered around the fifth decade	The extremities, head, and neck	Superior	SRF-NCOA2; MYOD1 mutation

ERMS: embryonal rhabdomyosarcoma.
ARMS: alveolar rhabdomyosarcoma.
PRMS: pleomorphic rhabdomyosarcoma.
SRMS: spindle cell/sclerosing rhabdomyosarcoma.