Sarcoma / 2015 / Article / Tab 2

Review Article

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

Table 2

The histological types of rhabdomyosarcoma.

Histological typePredilection populationPredilection siteRisk categoryGenetic change

ERMSInfants or children under 10 years oldHead and neck regionIntermediateLOH at chromosome 11p15.5

ARMSAdolescents and young adultsDeep tissue of extremityHight(2;13)(q35;q14); t(1;13)(p36;q14)

PRMSAdult males Throughout the bodyHighJUN (1p31), MYC (8q24), CCND1 (11q13), INT2 (11q13.3), MDM2 (12q14.3–q15)

SRMSIn the first decade of life with a second mode centered around the fifth decadeThe extremities, head, and neckSuperiorSRF-NCOA2; MYOD1 mutation

ERMS: embryonal rhabdomyosarcoma.
ARMS: alveolar rhabdomyosarcoma.
PRMS: pleomorphic rhabdomyosarcoma.
SRMS: spindle cell/sclerosing rhabdomyosarcoma.