Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

Table 4

MicroRNAs involved in myogenesis and RMS development.

miRNA	Expression	Target	Function	Reference
miR-1 and miR-133a	Downregulation	MYH9	Myogenic miRNA, inhibit differentiation and promote proliferation in myogenesis, cytostatic	Rao et al., 2010 [42]
miR-206	Downregulation	cMET	Promote differentiation and proliferation in myogenesis	Yan et al., 2009 [43]
miR-29	Downregulation	HADC4, YY1, EZH2	Promote stabilization of RMS phenotype	Marchesi et al., 2014 [44]
miR-450-5p	Downregulation	ENOX, PAX9	Promote differentiation and progression	Sun et al., 2014  [45]
miR-203	Downregulation	JAK, STAT, Notch	Inhibit differentiation and proliferation in myogenesis, tumor suppressor	Diao et al., 2014 [46]
miR-214	Downregulation	N-Ras	Inhibit tumor cell growth and induce myogenic differentiation and apoptosis	Huang et al., 2014 [47]
miR-183	Upregulation	EGR1	Promote migration and metastasis	Sarver et al., 2010 [48]