Myeloablative Chemotherapy with Autologous Stem Cell Transplant for Desmoplastic Small Round Cell Tumor

Table 2

Myeloablative chemotherapy and autologous stem cell transplant: toxicities and response.

Pt#	Residual disease before ASCT	MA	Carboplatin dose (per m^2)	Source of SC	Dose of SC (10^6 CD34+ cells/kg)	Time (days); to ANC >500	Time (days) to platelet count >20 K	Major acute nonhematological toxicities	Response ASCT
First complete remission before ASCT
1	None	CT	700	PB + BM	3.0	13	51	Grade 3 hyperbilirubinemia, grade 3 hematuria	N/A
2	None	CT	500	BM	4.1	14	48	Grade 3 sepsis	N/A
3	None	CTT	700	PB	17.5	13	11	Grade 4 mucositis, grade 3 SGOT elevation	N/A
4	None	CT	700	PB + BM	3.4	13	34	None	N/A
5	None	CT	600	BM	5.6	9	28	Grade 3 diarrhea	N/A
6	None	CT	500	BM	3.2	13	26	Grade 3 hyperbilirubinemia, grade 3 mucositis	N/A
7	None	CT	450	PB	4.4	9	9	Grade 3 mucositis	N/A
8	None	CT	400	PB	UA	12	15	Grade 3 diarrhea, grade 3 vomiting	N/A
Persistent but chemosensitive disease before ASCT
9	Abdomen	CT	500	BM	2.4	23	57	None	SD
10	Abdomen	CT	400	BM	2.6	11	16	Grade 3 mucositis	SD
11	Abdomen, pelvis, mediastinum	CT	425	PB	2.1	12	13	Grade 4 hyperbilirubinemia, grade 3 mucositis	Minor
12	Abdomen, mediastinum	CT	600	PB	7.2	9	14	Grade 4 sepsis	SD
13	Abdomen	CT	700	BM	3.1	14	41	Grade 4 hyperbilirubinemia	Lost to followup
14	Abdomen, mediastinum	CTT	500	PB	6.2	10	10	Grade 3 mucositis	SD
15	Abdomen, pelvis, mediastinum	CT	500	PB	4.1	6	13	Grade 3 hyperbilirubinemia, grade 3 vomiting	SD
16	Abdomen	CT	500	BM	2.4	10	11	Grade 3 hypertension, grade 3 mucositis	PD
Relapse before ASCT
17	Mediastinum	CT	600	PB	5.1	9	15	Grade 3 vomiting	SD
18	None	CT	500	PB	5.0	10	13	Grade 3 mucositis, grade 3 diarrhea, grade 3 hematuria	N/A
19	Abdomen, axilla	CTT	600	PB + BM	UA	11	16	Grade 3 hyperbilirubinemia, grade 4 sepsis, grade 4 hearing loss, grade 4 hematuria, grade 3 mucositis	SD

ANC: absolute neutrophil count; ASCT: autologous stem cell transplant; BM: bone marrow; CT: carboplatin and thiotepa; CTT: carboplatin and thiotepa plus topotecan; FU: followup; MA: myeloablative chemotherapy; N/A: not applicable; PB: peripheral blood; PD: progressive disease; SC: stem cells; SD: stable disease; UA: details of dose unavailable.