Research Article

Improvement in Overall Survival from Extremity Soft Tissue Sarcoma over Twenty Years

Table 3

Hazard ratios and 95% confidence intervals from multivariate analysis of a 20-year period.

CharacteristicHazard ratio95% CI value

Year of diagnosis
 2004–2010Reference group
 1991–19963.0212.775, 3.290<0.0001*
 1997–20032.2122.063, 2.371<0.0001*
Sex
 MaleReference group
 Female0.8080.762, 0.856<0.0001*
Tumor location
 Lower limbReference group
 Upper limb0.9400.880, 1.0040.0657
Hispanic ethnicity
 Non-HispanicReference Group
 Hispanic0.8520.770, 0.9420.0217*
Radiationa
 NoReference Group
 Yes0.7990.753, 0.848<0.0001*
Surgerya
 NoReference Group
 Yes0.4360.399, 0.476<0.0001*
Marital statusa
 MarriedReference Group
 Other1.4731.374, 1.578<0.0001*
 Single1.4511.322, 1.580<0.0001*
Age
 <30Reference Group
 30–591.6981.462, 1.972<0.0001*
 60+3.9263.371, 4.573<0.0001*
Geographic region
 WestReference Group
 Midwest0.9370.850, 1.032 0.1849
 Northeast1.1031.008, 1.2080.0323
 South0.9980.898, 1.1090.9740
Histology
 LipomatousReference Group
 All other types1.3801.201, 1.586<0.0001*
 Fibromatous1.1191.019, 1.2280.0187*
 Myomatous1.2661.134, 1.413<0.0001*
 Myxomatous0.9820.667, 1.4450.9267
 NOS1.5671.410, 1.740<0.0001*
 Synovial1.7081.493, 1.954<0.0001*
Gradea
 IReference Group
 II1.5571.352, 1.793<0.0001*
 III2.5812.260, 2.947<0.0001*
 IV2.8832.533, 3.282<0.0001*
Metastasis
 NoReference Group
 Yes3.3203.074, 3.587<0.0001*
Tumor Sizea
 <=5 cmReference Group
 >5 cm1.7431.620, 1.876<0.0001*
% Foreign bornb0.9920.988, 0.995<0.0001*
% < HS educationb1.0141.010, 1.019<0.0001*

Significant on a level.
NOS: not otherwise specified.
aHRs for variables with “unknown” values are not included in these results.
bHigh school graduation is based upon county-level 2000 census data.