Retinal Targets ALDH Positive Cancer Stem Cell and Alters the Phenotype of Highly Metastatic Osteosarcoma Cells

Figure 2

Retinal treatment of sorted ALDH-high K7M2 cells decreased antioxidative stress capacity. After cell sorting according to ALDH activity, it showed that the K7M2-ALDH high cells were more resistant to oxidative stress (H₂O₂, 250 µM for 1 hr) than the K7M2-ALDH low cells, while the retinal treatment of K7M2-ALDH high cells was able to greatly decrease their resistance to oxidative stress and resulted in more cell apoptosis. “” indicates that ALDH-high control cells are significant different () compared to ALDH-low control cells; “” indicates retinal treated ALDH-high or ALDH-low cells are significant different () compared to nontreated ALDH-high or ALDH-low control cells, respectively.