Sarcoma

Research Article

Epiphyseal Sparing and Reconstruction by Frozen Bone Autograft after Malignant Bone Tumor Resection in Children

Table 1

Descriptive criteria of all cases.


Number	Age	Sex	Diagnosis	Location	Outcome	Freezing	Margin	Histological response	Function	FU

1	11	M	Osteosarcoma	Femur	CDF	Free freezing	Marginal	RH III/IV	Excellent	70
2	10	M	Osteosarcoma	Femur	CDF	Free freezing	Marginal	RH III/IV	Excellent	66
3	16	M	Osteosarcoma	Femur	CDF	Free freezing	Marginal	RH IV/IV	Excellent	63
4	6	F	Osteosarcoma	Femur	CDF	Free freezing	marginal	RH III/IV	Excellent	54
5	13	F	Osteosarcoma	Femur	CDF	Free freezing	Marginal	RH III/IV	Excellent	53
6	16	M	Undifferentiated round cell sarcoma	Calcaneus	CDF	Pedicle freezing	Wide	Total necrosis RH IV/IV	Excellent	53
7	11	F	Osteosarcoma	Tibia	CDF	Free freezing	Marginal	RH III/IV	Excellent	95
8	12	F	Osteosarcoma	Tibia	CDF	Pedicle freezing	Marginal	Total necrosis RH IV/IV	Excellent	87
9	16	F	Osteosarcoma	Tibia	NED	Free freezing	Wide	RH III/IV	Excellent	155
10	8	F	Osteosarcoma	Femur	NED	Free freezing	Wide	RH IV/IV	Excellent	90
11	13	F	osteosarcoma	femur	NED	pedicle freezing	Wide	RH III/IV	excellent	79
12	14	M	osteosarcoma	tibia	NED	pedicle freezing	Marginal	a few viable tumor cells	excellent	85
13	15	M	osteosarcoma	femur	NED	free freezing	Wide	RH III/IV	excellent	69
14	15	M	osteosarcoma	tibia	NED	pedicle freezing	Wide	RH III/IV	excellent	54
15	10	F	Osteosarcoma	tibia	NED	pedicle freezing	Marginal	RH III/IV	excellent	50
16	6	M	osteosarcoma	femur	AWD	free freezing	Wide	RH III/IV	poor	58
17	18	F	osteosarcoma	tibia	AWD	pedicle freezing	Wide	RH III/IV	excellent	98
18	11	M	Ewing’s sarcoma	tibia	DOD	free freezing	Wide	RH III/IV	excellent	32

The following abbreviations were used; CDF: continuous disease free. NED: no evidence of disease. AWD: alive with the disease. DOD: died of the disease. FU: follow up. (): refers to cases who had a hemicortical resection.
RH: Rosen and Huvos Grade [15].
Grade I, little or no effect of chemotherapy noted; Grade II, a partial response to chemotherapy with greater than 50% tumor necrosis noted and attributable to preoperative chemotherapy; however, some histologic sections demonstrated areas of viable tumor; Grade III, greater then 90% tumor necrosis attributable to preoperative chemotherapy; however, foci of what appear to be viable tumor are seen in some histologic sections; and Grade IV, no viable-appearing tumor cells noted in any of the histologic sections.