Research Article
A Therapeutic Role for Survivin in Mitigating the Harmful Effects of Ionizing Radiation
Figure 1
Fractionated radiation therapy was selectively administered to each animal. A specialized jig was designed and built out of lead in order to ensure that only the gene-modified dorsal aspect of the left hind leg was exposed to the radiation beam (a, b). Five animals at a time were anesthetized and placed in a radiation chamber where they were exposed to 5 Grays of radiation at a dosage rate of 1 Gy/min (c). This protocol was carried out for ten consecutive days for a cumulative dose of 50 Gy/animal.
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