Notch Signaling Mediates Skeletal Muscle Atrophy in Cancer Cachexia Caused by Osteosarcoma

Figure 4

In vivo inhibition of Notch signaling in tumor-bearing mice reduced skeletal muscle atrophy. (a) Notch inhibitor MK-0752 (50 mg/kg) was injected starting two weeks after K7M2 cell injection, three times a week for four weeks. The size of the primary osteosarcoma tumor was unaffected by MK-0752 injection. mice in each group. (b) Trichrome staining showing decreased fibrosis formation in muscles with Notch inhibition. (c) Differential myofiber size with and without MK-0752 injection. “” in the bar chart indicates .

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