Research Article

HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi’s Sarcoma during AIDS

Table 2

Number (and percent) of codons under positive or negative selection in tumor and nontumor sites in env sequence populations.

PatientTissue# positively selected sites (%)Codon position of shared positively selected sites# negatively selected sitesCodon position of shared negatively selected sites

KS1 (359)Skin tumor7 (1.9)None7 (1.9)na
Lymph node tumor1 (0.3)None7 (1.9)122
NontumorNoneNone8 (2.2)122

KS2 (394)Skin tumor8 (2.0)4645 (1.2)150
Small bowel tumorNoneNoneNoneNone
Nontumor5 (1.2)3734 (1.0)150

KS3 (373)Skin tumor3 (0.8)4646 (1.6)207, 247
Small bowel tumor10 (2.6)183, 336, 39616 (4.2)103, 118, 207, 228, 238, 246, 254, 276, 374, 408, 415, 445
Nontumor11 (2.9)143, 167, 183, 336, 45421 (5.6)103, 118, 207, 228, 238, 246, 254, 276, 374, 408, 415, 445