HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi’s Sarcoma during AIDS

Table 3

Number (and percent) of codons under positive or negative selection in tumor and nontumor sites in nef sequence populations.

Patient	Tissue	# positively selected sites	Codon position of shared positively selected sites	# negatively selected sites	Codon position of shared negatively selected sites
KS1 (207)	Skin tumor	0	None	3 (1.5)	188
	Lymph node tumor	4 (1.9)	None	18 (8.7)	8, 37, 188
	Nontumor	1 (0.5)	None	4 (1.9)	8, 37, 188
KS2 (205)	Skin tumor	1 (0.5)	190	0	None
	Small bowel tumor	1 (0.5)	190	4 (2.0)	81
	Nontumor	2 (1.0)	190	5 (2.4)	81
KS3 (207)	Skin tumor	1 (0.5)	None	7 (3.4)	30, 65, 147, 151, 191, 195
	Small bowel tumor	1 (0.5)	None	14 (6.8)	4, 30, 63, 65, 111, 129, 151, 164, 191, 195
	Nontumor	1 (0.5)	None	21 (10.1)	4, 63, 111, 129, 147, 151, 164, 191, 195