Ewing’s Sarcoma as a Second Malignancy in Long-Term Survivors of Childhood Hematologic Malignancies

Figure 3

(a) Coronary T1 MRI section demonstrating a large mass (arrow) of the right mandible with infiltration and displacement of the tongue of patient 3. (b) Biopsy of the intraoral mass of patient 3. Diffuse infiltrates of a small, blue round, undifferentiated tumor with strong immunohistochemical membranous expression of CD99 (brown reaction product shown in the inset) (H&E; original magnification 100x). (c) Fluorescence in situ hybridization (FISH) of the jaw tumor of patient 3, demonstrating the rearrangement of the EWSR1 gene. The nuclei of the tumor cells contain one fused signal (arrow head) and one pair of split green and red signals (arrows).

(a)

(b)

(c)