Clinical Study

Concurrent Imatinib and Radiation Therapy for Unresectable and Symptomatic Desmoid Tumors

Table 1

Summary of patient characteristics and response to treatment.

AgeSexSiteSymptomsRadiation doseRadiation toxicityImatinib toxicitySymptom relief (days)Follow-up (months)Change in volume

52MR backPain50 Gy in 25 fxGrade 1 fatigueGrade 2 nausea712−93%PR
70FL axillaPain, weakness, and numbness54 Gy in 27 fxGrade 2 fatigue, Grade 1 dermatitis, L breast edemaGrade 2 fatigue, Grade 2 nausea36018−69%SD
47FL axillaPain and numbness50.4 Gy in 28 fxGrade 2 dermatitis, AVN of L humeral headGrade 1 nausea1363−8%SD
63MR neck and upper backPain50 Gy in 25 fxGrade 2 dermatitisGrade 2 nausea, Grade 2 dysgeusia424−28%SD

M = male, F = female, R = right, L = left, and fx = fractions. on change in largest diameter, PR = partial response, SD = stable disease, and AVN = avascular necrosis.