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Volume 2017, Article ID 5419394, 8 pages
Research Article

Preoperative Factors Associated with Infiltrative Histologic Growth Patterns in Extremity Soft Tissue Sarcoma

1Department of Orthopaedic Surgery, Seoul National University Hospital, Seoul, Republic of Korea
2Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea
3Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea

Correspondence should be addressed to Ilkyu Han;

Received 1 February 2017; Revised 6 May 2017; Accepted 19 June 2017; Published 20 July 2017

Academic Editor: R. Lor Randall

Copyright © 2017 Jong Woong Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Soft tissue sarcoma (STS) with an infiltrative histologic growth pattern, when compared to STS with an expansile pattern, may pose difficulties in local control. Preoperative assessment of the presence of infiltrative histologic growth pattern would be helpful in deciding treatment strategies. A review of 144 patients who underwent surgery for extremity STS was performed. Microscopically, the histologic growth pattern was defined as infiltrative if the penetration of the tumor cells into the surrounding tissue was observed. Possible clinicopathologic factors that might be associated with infiltrative histologic growth pattern were investigated with regard to patient demographics, tumor characteristics, and MRI findings. Of the 144 tumors, 71 (49%) showed infiltrative histologic growth pattern. On multivariate analysis, histological subtypes other than liposarcoma (OR = 4.57, ) and infiltrative border on MRI (OR = 2.48, ) were independent factors associated with infiltrative histologic growth pattern. Predictive index based on these two factors showed a significant improved accuracy (ROC-AUC = 0.647) for predicting infiltrative histologic growth pattern compared to either factor alone. Our data suggests that liposarcoma histology and tumor border on MRI can predict histologic growth pattern in extremity STS.