SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors

Table 1

Patient characteristics at enrollment and response evaluation.

Stratum	NF1 MPNST	Sporadic MPNST
Eligible patients enrolled	34	14
Male/female	22/12	9/5
Median age: years (range)	33 (8–66)	40 (13–72)
Race: (%)
White, non-Hispanic	14 (41%)	11 (79%)
Black	13 (38%)	2 (14%)
Hispanic	4 (12%)	0 (0%)
Other/unknown	3 (9%)	1 (7%)
ECOG score: 0/1/2	4/24/6	6/5/3
Disease: localized/metastatic	18/16	5/9
Location
Head	2	0
Neck	3	1
Chest	10	4
Abdomen/pelvis	9	5
Spine	5	1
Upper extremity	3	1
Lower extremity	2	2
Response evaluation after cycle 4	28	9
Complete response (CR)	—	—
Partial response (PR)	5	4
Stable disease (SD)	20	4
Progressive disease (PD)	3	1
Objective response rate: %	17.9	44.4