High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients
Table 6
Univariate analysis of overall and event-free survival.
Survival
Number of patients
Percent
Event-free survival
Overall survival
Variable
5 year (%)
SE (%)
(log-rank)
5 year (%)
SE (%)
(log-rank)
Total
23
Age
<32 years (median)
12
52
64
15
0.438
61
15
0.828
>32 years
11
48
39
21
67
20
Sex
Male
13
57
44
18
0.791
39
17.5
0.235
Female
10
43
63
18
89
10.5
Tumor site
Tarsus
16
70
49
16
0.903
57
15
0.503
Other
7
30
71
17
80
18
Tumor size
<31.5 cm3 (median)
5
50
80
18
0.786
80
18
0.366
>31.5 cm3
5
50
67
27
67
27
Primary metastases
No
20
87
66
13
0.005
78
11
0.008
Yes
3
13
0
0
0
0
AP
Normal
15
75
60
16
0.216
57
16
0.568
Elevated
5
25
30
24
53
25
LDH
Normal
16
84
68
14
0.076
62
15
0.291
Elevated
3
16
0
0
33
27
Duration of symptoms
<154 days (median)
11
55
76
16
0.188
76
16
0.463
>154 days
9
45
29
22
51
20
Delay of chemotherapy
<21 days
8
35
58
19
0.532
73
17
0.441
>21 days
15
65
52
17
57
17
Timing of operation
After preoperative chemotherapy
18
78
52
14
0.929
64
13
0.587
Primary surgery
5
22
67
27
67
27
Type of surgery
Resection
4
17
75
22
0.660
75
22
0.347
Amputation
19
83
45
15
60
14
Surgical remission
Complete remission
21
95
60
13
0.000
72
12
0.000
Macroscopic residual
2
9
0
0
0
0
Tumor response
Good
4
24
38
29
0.980
67
27
0.435
Poor
13
76
64
15
59
16
5-year event-free and overall survival and values in the log-rank test for all variables (see Data collection and Definition of Variables). SE = standard error; = two-sided values.
