Role of High-Dose Chemotherapy and Autologous Hematopoietic Cell Transplantation for Children and Young Adults with Relapsed Ewing’s Sarcoma: A Systematic Review

Table 4

Retrospective abstracts consisting of mixture of patients with primary metastatic and relapsed Ewing’s sarcoma.

Study	Average age (years)	Number of pts	Chemotherapy	HDCT	Number of Tx prior to SCT	Source of stem cell	Response (number of pts)	EFS	OS
Elhasid et al. 2012, retrospective [34]	14	Total (16)	NL	Melphalan (NL); Busulfan (NL)	NL	NL	NL	8 yr EFS 41%	6 yr OS 56%
Cristofani et al. 2013, retrospective [35]	7	Total (18)	NL	NL	NL	PSBC; BSC	NL	NL	5 yr OS 33%
Thiel et al. 2014, retrospective [36]	NL	Total (8); Relapsed (2)	NL	NL	NL	NL	CR (7)	Median EFS 16.5 months	2.5 yr OS 62%

NL: not listed, HDCT: high-dose chemotherapy, SCT: stem cell transplant, PBSC: peripheral blood stem cell, BSC: bone marrow stem cell, EFS: event-free survival, OS: overall survival, and CR: complete remission.