Aerosol Gemcitabine after Amputation Inhibits Osteosarcoma Lung Metastases but Not Wound Healing

Figure 2

Aerosol GCB inhibited lung metastases but had no effect on wound healing in the tail, dorsal skin, or bone. (a) Representative appearance of the dorsal wound on days 1 and 10 in the mice treated with aerosol PBS (top row) or aerosol GCB (bottom row). (b) The areas of each wound in the aerosol PBS and aerosol GCB groups were measured 1, 4, 7, and 10 days after treatment ( for each group). (c) Representative H&E sections from the wounded tail, dorsal skin, and postamputation area 7 days following wounding. (d–f) Aerosol GCB inhibited the growth of osteosarcoma lung metastases as assessed visually (d), by the lung weight (e), and by the mean number of lung metastases (f) ().

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