Research Article

Treatment Patterns and Survival among Adult Patients with Advanced Soft Tissue Sarcoma: A Retrospective Medical Record Review in the United Kingdom, Spain, Germany, and France

Table 1

Histologic categories.

Histologic category used in analysisHistologic subtypes reported in the medical recordCorresponding WHO histologic category and subtypesa

LeiomyosarcomaSmooth-muscle tumor and uterine leiomyosarcomaSmooth-muscle tumor (i.e., leiomyosarcoma and leiomyoma of deep soft tissue)

Fibroblastic/myofibroblastic sarcomaFibroblastic/myofibroblastic sarcomaFibroblastic/myofibroblastic sarcoma (i.e., fibrosarcoma, myxofibrosarcoma, low-grade fibromyxoid sarcoma, and sclerosing epithelioid fibrosarcoma)

LiposarcomaAdipocytic tumorAdipocytic tumor (i.e., dedifferentiated liposarcoma, myxoid liposarcoma, and pleomorphic liposarcoma)

Vascular sarcomaVascular tumor of soft tissue and angiosarcomaVascular tumor (epithelioid hemangioendothelioma and angiosarcoma of soft tissue)

RhabdomyosarcomaSkeletal-muscle tumorSkeletal-muscle tumor (i.e., rhabdomyosarcoma, including embryonal, alveolar, and pleomorphic forms, and spindle cell/sclerosing rhabdomyosarcoma)

Synovial sarcomaSynovial sarcomaTumor of uncertain differentiation: synovial sarcoma

Others or not otherwise specified (NOS)Chondro-osseous tumor, fibrohistiocytic tumor, pericytic tumor, nerve sheath tumor, tumor of uncertain differentiation, and undifferentiated/unclassified sarcomaNot applicable
So-called fibrohistiocytic tumor
Perivascular tumor
Chondro-osseous tumor
Nerve sheath tumor
Tumor of uncertain differentiation (unless otherwise notedb)
Undifferentiated/unclassified tumor

WHO: World Health Organization; aaccording to the WHO classification of tumours of soft tissue and bone [8]; bsynovial sarcoma, classified under “Tumours of uncertain differentiation,” was included in a separate histologic category for the analyses.