Research Article
Radiation Therapy for Retroperitoneal Sarcomas: Influences of Histology, Grade, and Size
Table 1
Patient clinical and demographic characteristics categorized by receipt of perioperative radiation.
| | Resection alone | Resection + radiation therapy | |
| | | | | Median age (IQR) | 61 [52–70] | 59 [51–68] | 0.002 | Female sex | 53.0% | 53.2% | 0.939 | Race | | | 0.034 | Caucasian | 84.4% | 80.9% | | African American | 9.7% | 13.3% | | Others | 5.9% | 5.8% | | Charlson-Deyo score | | | 0.607 | 0 | 82.2% | 83.2% | | 1 | 17.8% | 16.8% | | Facility type | | | <0.001 | Nonacademic | 31.5% | 40.3% | | Academic/research | 62.9% | 52.1% | | Missing | 5.6% | 7.6% | | Histology | | | <0.001 | Liposarcoma | 67.1% | 46.4% | | Leiomyosarcoma | 21.5% | 35.8% | | Undifferentiated Pleomorphic | | | | Sarcoma | 2.0% | 3.2% | | Sarcoma, NOS | 9.3% | 14.7% | | Operation | | | 0.514 | Simple/partial resection | 28.5% | 26.1% | | Total resection | 23.9% | 25.7% | | Debulking | 4.9% | 5.8% | | Radical resection | 42.6% | 42.4% | | Chemotherapy | | | <0.001 | No chemotherapy | 86.7% | 79.8% | | Chemotherapy | 10.7% | 16.9% | | Missing | 2.7% | 3.3% | | Median tumor size (IQR) (cm) | 19.0 [12.0–29.0] | 15.0 [9.0–20.6] | <0.001 | Tumor size category | | | <0.001 | <15 cm | 36.8% | 52.5% | | >15 cm | 63.2% | 47.5% | | Grade | | | <0.001 | Low | 48.8% | 36.3% | | High | 40.3% | 51.9% | | Missing | 10.9% | 11.8% | | Margin status | | | <0.001 | Negative | 52.6% | 51.7% | | Positive | 32.1% | 39.6% | | Missing | 15.3% | 8.7% | | 30-day readmission (unplanned) | 6.1% | 5.0% | <0.001 | Median hospital stay (days) | 6 | 6 | 0.177 | 90-day mortality | 4.3% | 2.1% | 0.013 | Median OS (months) | 82.7 | 95.8 | <0.001 | Interval survival (95% CI) | | | | 1 year | 88.3% | 92.7% | | 2 year | 80.1% | 84.2% | | 3 year | 71.7% | 74.9% | | 5 year | 58.9% | 61.6% | | 10 year | NR | 4.0% | |
|
|