High Recurrence Rate of Myxofibrosarcoma: The Effect of Radiotherapy Is Not Clear

Table 3

Univariate analysis of risk factors for local recurrence in all tumors.

	No LR	LR	value (log-rank test)	HR for LR	95% CI (Cox regression)
Median tumor size (range; cm)	6 (2–18)	8 (3–17)	0.4
>5 cm	26	11
<5 cm	15	4
Tumor site			0.5
Upper extremity	12	5
Lower extremity	26	10
Trunk wall	3	0
Tumor depth			0.7
Subcutaneous	19	7
Deep	22	8
Place where the primary surgery was performed			0.2
Sarcoma center	34	10
Outside of the center	7	5
Final surgical margin
Intralesional	4	3		9.4	2.0–43.5	0.004
Marginal	11	8		4.5	1.3–15.1	0.02
Wide	26	4		—	—	—
Necrosis			0.3
Yes	21	10
No	16	4
Not determined	4	1
Vascular invasion			0.6
Yes	6	1
No	31	11
Not determined	4	3
Growth pattern			N/A
Infiltrative	26	11
Pushing	0	0
Not determined	15	4
Malignancy grade			0.1
High grade	32	14
Low grade	9	1
Adjuvant treatment
None	15	6		—	—	—
Radiotherapy	17	6		0.7	0.2–2.3	0.6
Chemotherapy	1	0		N/A
Radio- and chemotherapy	8	3		1.0	0.2–3.9	1.0