High Recurrence Rate of Myxofibrosarcoma: The Effect of Radiotherapy Is Not Clear

Table 4

Univariate analysis of risk factors for metastasis among high-grade tumors.

	No metastasis	Metastasis	value (log-rank test)	HR for LR (Cox regression)	95% CI
Median tumor size (range; cm)	6.0 (2–17)	11.0 (5–18)	0.02
>5 cm	22	13
<5 cm	11	0
Tumor site			0.6
Upper extremity	12	4
Lower extremity	19	9
Trunk wall	2	0
Tumor depth			0.6
Subcutaneous	15	4
Deep	18	9
Place where the primary surgery was performed			0.6
Sarcoma center	25	11
Outside of the center	8	2
Final surgical margin
Intralesional	4	2		6.4	1.1–39	0.04
Marginal	11	8		2.8	0.9–13	0.07
Wide	18	3		—	—	—
Necrosis			0.2
Yes	20	10
No	11	2
Not determined	2	1
Vascular invasion			0.5
Yes	5	2
No	25	9
Not determined	3	2
Growth pattern			N/A
Infiltrative	22	8
Pushing	0	0
Not determined	11	5
Adjuvant treatment
None	10	3		—	—	—
Radiotherapy	15	6		0.8	0.2–3.3	0.8
Chemotherapy	0	1		1.7	0.2–16	0.7
Radio- and chemotherapy	8	3		0.9	0.2–4.5	0.9