Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution

Table 3

Prognostic factors for overall survival and progression-free survival in all patients with dedifferentiated chondrosarcoma by multivariate analysis.

Variable	Overall survival			Progression-free survival
	HR	95.0% CI		HR	95.0% CI
Pathological fracture
No	1.00			1.00
Yes	2.77	1.53–5.03	0.001	2.97	1.66–5.30	<0.001
Tumor size
≤8 cm	1.00		0.001			NS
>8 cm	3.43	1.73–6.79	<0.001
Discontinuous	3.73	0.96–14.56	0.058
Lymph node involvement
No	1.00					NS
Yes	5.27	1.26–22.08	0.023
Distant metastasis
No	1.00			1.00
Yes	5.31	2.63–10.74	<0.001	5.21	2.73–9.95	<0.001
Extraosseous extension
No	1.00					NS
Yes	5.24	1.11–24.70	0.036
UPS component
No	1.00					NS
Yes	2.44	1.31–4.57	0.005
Surgical resection
No	1.00					NS
Yes	0.21	0.08–0.55	0.002
Chemotherapy
No	1.00			1.00
Yes	0.23	0.12–0.44	<0.001	0.43	0.24–0.77	0.005

CI, confidence interval; HR, hazard ratio; NS, not significant; UPS, undifferentiated pleomorphic sarcoma.